Fredric March

Samuel Langhorne Clemens (Mark Twain)

Alexis Smith

Olivia Langdon Clemens

Donald Crisp

J.B. Pond

Alan Hale

Steve Gillis

C. Aubrey Smith

Oxford Chancellor

John Carradine

Bret Harte

Robert Barrat

Horace E. Bixby, Riverboat Captain

Walter Hampden

Jervis Langdon

Joyce Reynolds

Clara Clemens

William Henry

Charles Langdon

Charles Waldron

Dr. Quintard (uncredited)

Willie Best

Butler

Nana Bryant

Mrs. Langdon

Dickie Jones

Young Samuel Clemens